Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165449 | 0.81 | TSHR (0.44) | HTR1AADRA1DADRA1AADRA1BTSHR | |
| SCHEMBL29784889 | 0.81 | TSHR (0.44) | HTR1AADRA1DADRA1AADRA1BTSHR | |
| SCHEMBL22297588 | 0.79 | KDM4E (0.52) | MAPK1TSHRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL16668774 | 0.77 | TSHR (0.55) | MAPK1TSHRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7520673 | 0.77 | ALDH1A1 (0.52) | MAPK1TSHRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9369921 | 0.75 | KCNA3 (0.50) | CYP1A2CYP2C19ALDH1A1MAPTRAB9A | |
| SCHEMBL15723552 | 0.75 | MAPK1 (0.58) | MAPK1TSHRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6089615 | 0.74 | ABCB1 (0.46) | HTR1AALDH1A1MAPTRAB9A | |
| SCHEMBL6091732 | 0.74 | CHRNB2 (0.51) | HTR1AADRA1DADRA1AADRA1BCYP2D6 | |
| SCHEMBL27333271 | 0.74 | NPC1 (0.44) | MAPK1HTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |