Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 7/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375312 | 0.82 | CYP3A4 (0.43) | CYP3A4CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL6457239 | 0.79 | CYP3A4 (0.41) | CYP3A4CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL28190550 | 0.76 | CYP3A4 (0.44) | CYP3A4CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL7363839 | 0.75 | CYP1A2 (0.33) | CYP3A4CYP1A2CYP2C9CYP2C19MAP2K1 | |
| SCHEMBL28394725 | 0.75 | KDM1A (0.34) | KDM4EALDH1A1MAPTKDM1ATSHR | |
| SCHEMBL4618271 | 0.75 | TSHR (0.33) | CYP3A4CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL9843984 | 0.74 | CYP3A4 (0.36) | CYP3A4CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL10581584 | 0.74 | CD44 (0.45) | CYP3A4CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL10890690 | 0.74 | TSHR (0.43) | CYP3A4CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL6742592 | 0.74 | CYP3A4 (0.43) | CYP3A4CYP1A2CYP2C9CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6998489-B2 | Methods of making indazoles | ALCON, INC. (CH) | 2006-02-14 | — | — | US | disclosed |
| EP-1392659-A4 | METHODS OF MAKING INDAZOLES | ALCON INC (CH) | 2004-10-20 | — | — | EP | disclosed |
| US-20040142998-A1 | Methods of making indazoles | ALCON, INC. (CH) | 2004-07-22 | — | — | US | disclosed |
| EP-1392659-A1 | METHODS OF MAKING INDAZOLES | Alcon, Inc. (CH) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002098862-A1 | METHODS OF MAKING INDAZOLES | ALCON, INC. (CH) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142998-A1 | Methods of making indazoles | NAT1, CYP3A5, ALDH3A1 | CYP3A4 17/4885CYP1A2 11/4885CYP2C9 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.