Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 8/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.44 |
| ▸ | TLK2 | Q86UE8 | 5/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089797 | 1.00 | RET (0.53) | RETPDPK1KDRPDGFRBTLK2 | |
| SCHEMBL6092365 | 0.80 | PDPK1 (0.50) | RETPDPK1KDRPDGFRBTLK2 | |
| SCHEMBL6092360 | 0.80 | PDPK1 (0.50) | RETPDPK1KDRPDGFRBTLK2 | |
| SCHEMBL6091336 | 0.80 | RET (0.37) | RETKDRRPS6KA3ALDH1A1MAPT | |
| SCHEMBL6091333 | 0.80 | RET (0.37) | RETKDRRPS6KA3ALDH1A1MAPT | |
| SCHEMBL6088131 | 0.80 | RET (0.37) | RETKDRRPS6KA3ALDH1A1MAPT | |
| SCHEMBL6088124 | 0.80 | RET (0.37) | RETKDRRPS6KA3ALDH1A1MAPT | |
| SCHEMBL6089866 | 0.80 | KDR (0.34) | RETKDRRPS6KA3ALDH1A1MAPT | |
| SCHEMBL6089871 | 0.80 | KDR (0.34) | RETKDRRPS6KA3ALDH1A1MAPT | |
| SCHEMBL6088538 | 0.77 | KDR (0.33) | RETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |