Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 7/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091333 | 1.00 | RET (0.37) | RETRPS6KA3KDRALDH1A1HPGD | |
| SCHEMBL6088131 | 0.86 | RET (0.37) | RETRPS6KA3KDRALDH1A1HPGD | |
| SCHEMBL6088124 | 0.86 | RET (0.37) | RETRPS6KA3KDRALDH1A1HPGD | |
| SCHEMBL6089871 | 0.81 | KDR (0.34) | RETRPS6KA3KDRALDH1A1MEN1 | |
| SCHEMBL6089866 | 0.81 | KDR (0.34) | RETRPS6KA3KDRALDH1A1MEN1 | |
| SCHEMBL6089792 | 0.80 | RET (0.53) | RETRPS6KA3KDRALDH1A1MAPT | |
| SCHEMBL6089797 | 0.80 | RET (0.53) | RETRPS6KA3KDRALDH1A1MAPT | |
| SCHEMBL6090556 | 0.77 | ADORA2B (0.43) | ALDH1A1HPGDKDM4ETSHRHSD17B10 | |
| SCHEMBL6090474 | 0.76 | ALK (0.40) | RETKDRALDH1A1HPGDKDM4E | |
| SCHEMBL6090470 | 0.76 | ALK (0.40) | RETKDRALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |