Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089787 | 1.00 | KDR (0.42) | KDRALKMMP2MMP13MMP14 | |
| SCHEMBL6089402 | 0.87 | KDR (0.52) | KDRALKABL1RETPDGFRB | |
| SCHEMBL6089417 | 0.87 | KDR (0.52) | KDRALKABL1RETPDGFRB | |
| SCHEMBL6089380 | 0.84 | ALK (0.56) | KDRALKMMP2MMP13MMP14 | |
| SCHEMBL6089385 | 0.84 | ALK (0.56) | KDRALKMMP2MMP13MMP14 | |
| SCHEMBL6088717 | 0.82 | ABL1 (0.40) | KDRALKABL1RETPDGFRB | |
| SCHEMBL6088711 | 0.82 | ABL1 (0.40) | KDRALKABL1RETPDGFRB | |
| SCHEMBL6093374 | 0.82 | ALK (0.41) | KDRALKMMP2MMP13MMP14 | |
| SCHEMBL6093367 | 0.82 | ALK (0.41) | KDRALKMMP2MMP13MMP14 | |
| SCHEMBL6088582 | 0.81 | NPSR1 (0.44) | ALKABL1RETPDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |