Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089402 | 1.00 | KDR (0.52) | KDRCHEK1KDM4EALDH1A1ABL1 | |
| SCHEMBL6089795 | 0.87 | KDR (0.42) | KDRKDM4EALDH1A1ABL1RET | |
| SCHEMBL6089787 | 0.87 | KDR (0.42) | KDRKDM4EALDH1A1ABL1RET | |
| SCHEMBL6088717 | 0.83 | ABL1 (0.40) | KDRKDM4EALDH1A1ABL1RET | |
| SCHEMBL6088711 | 0.83 | ABL1 (0.40) | KDRKDM4EALDH1A1ABL1RET | |
| SCHEMBL6090600 | 0.83 | KDR (0.61) | KDRCHEK1KDM4EALDH1A1ABL1 | |
| SCHEMBL6090612 | 0.83 | KDR (0.61) | KDRCHEK1KDM4EALDH1A1ABL1 | |
| SCHEMBL6089434 | 0.82 | ADORA2B (0.48) | KDRKDM4EALDH1A1ABL1RET | |
| SCHEMBL6089440 | 0.82 | ADORA2B (0.48) | KDRKDM4EALDH1A1ABL1RET | |
| SCHEMBL6089001 | 0.81 | ABL1 (0.45) | KDRKDM4EALDH1A1ABL1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |