Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6093367 | 1.00 | ALK (0.41) | ALKRAB9ANPC1KDRDCTPP1 | |
| SCHEMBL6089380 | 0.84 | ALK (0.56) | ALKRAB9ANPC1KDRMMP2 | |
| SCHEMBL6090412 | 0.84 | KDR (0.53) | ALKRAB9ANPC1KDRABL1 | |
| SCHEMBL6089385 | 0.84 | ALK (0.56) | ALKRAB9ANPC1KDRMMP2 | |
| SCHEMBL6090425 | 0.84 | KDR (0.53) | ALKRAB9ANPC1KDRABL1 | |
| SCHEMBL6089795 | 0.82 | KDR (0.42) | ALKNPC1KDRMMP2MMP13 | |
| SCHEMBL6089787 | 0.82 | KDR (0.42) | ALKNPC1KDRMMP2MMP13 | |
| SCHEMBL6090504 | 0.80 | ALK (0.41) | ALKRAB9ANPC1KDRDCTPP1 | |
| SCHEMBL6090494 | 0.80 | ALK (0.41) | ALKRAB9ANPC1KDRDCTPP1 | |
| SCHEMBL6090672 | 0.80 | TP53 (0.42) | ALKABL1RETPDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |