Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.30 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090999 | 0.89 | GFER (0.32) | MAP4K1 | |
| SCHEMBL6090481 | 0.88 | DAO (0.35) | PKMKDRGPR84MAP4K1 | |
| SCHEMBL6090485 | 0.88 | DAO (0.35) | PKMKDRGPR84MAP4K1 | |
| SCHEMBL6089530 | 0.86 | PDPK1 (0.34) | PDPK1ESR1ESR2LTA4HGPR84 | |
| SCHEMBL6089536 | 0.86 | PDPK1 (0.34) | PDPK1ESR1ESR2LTA4HGPR84 | |
| SCHEMBL6090443 | 0.80 | PDPK1 (0.45) | PDPK1PDGFRBFGFR1KDR | |
| SCHEMBL6091331 | 0.79 | CA12 (0.39) | PDPK1ESR1ESR2KDRHTT | |
| SCHEMBL6091332 | 0.79 | CA12 (0.39) | PDPK1ESR1ESR2KDRHTT | |
| SCHEMBL6091365 | 0.77 | ESR1 (0.33) | PDPK1ESR1ESR2GPR84EGFR | |
| SCHEMBL6088593 | 0.75 | GFER (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |