Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 3/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 3/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089693 | 1.00 | PDE4B (0.46) | PDE4BCASP1CASP8CASP3KMT2A | |
| SCHEMBL2821598 | 0.81 | PDE4B (0.54) | PDE4BKMT2AL3MBTL1HTTNPC1 | |
| SCHEMBL22234346 | 0.80 | KMT2A (0.52) | PDE4BKMT2AL3MBTL1HTTNPC1 | |
| SCHEMBL1722459 | 0.80 | PDE4B (0.51) | PDE4BKMT2AL3MBTL1HTTNPC1 | |
| SCHEMBL13456796 | 0.79 | KMT2A (0.55) | PDE4BKMT2AL3MBTL1HTTNPC1 | |
| SCHEMBL14428325 | 0.79 | KMT2A (0.55) | PDE4BKMT2AL3MBTL1HTTNPC1 | |
| SCHEMBL12164621 | 0.78 | MMP2 (0.49) | PDE4BKMT2AL3MBTL1HTTCTSL | |
| SCHEMBL21520375 | 0.78 | MMP2 (0.49) | PDE4BKMT2AL3MBTL1HTTCTSL | |
| SCHEMBL8830957 | 0.78 | MMP2 (0.49) | PDE4BKMT2AL3MBTL1HTTCTSL | |
| SCHEMBL21520377 | 0.78 | MMP2 (0.49) | PDE4BKMT2AL3MBTL1HTTCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7138395-B2 | Interleukin-1β converting enzyme inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2006-11-21 | — | — | US | disclosed |
| US-20040014753-A1 | Novel interleukin-1beta converting enzyme inhibitors | THE PROCTER & GAMBLE COMPANY | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014753-A1 | Novel interleukin-1beta converting enzyme inhibitors | IL1B, IL1RN, IL1R1 | PDE4B 2776/4885CASP1 41/4885CASP8 1129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.