SCHEMBL6090355

SCHEMBL6090355

Nc1ccc(CCC2=NNC(=O)C2=Cc2cc3ccccc3[nH]2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT1 Q96EB6 1/20 0.42
MAOB P27338 4/20 0.39
CYP2A6 P11509 1/20 0.38
CDK5 Q00535 1/20 0.36
CDK5R1 Q15078 1/20 0.36
AMY1A P0DUB6 1/20 0.34
MAPT P10636 3/20 0.34
RAB9A P51151 3/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
NPC1 O15118 2/20 0.34
LMNA P02545 1/20 0.34
ALDH1A1 P00352 1/20 0.34
MAOA P21397 2/20 0.33
IDO1 P14902 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
MAPK1 P28482 1/20 0.33
CYP2C19 P33261 1/20 0.33
PRF1 P14222 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6091646 1.00 SIRT1 (0.42) SIRT1MAOBCYP2A6CDK5CDK5R1
SCHEMBL6089199 0.91 SIRT1 (0.46) SIRT1MAOBCYP2A6AMY1AMAPT
SCHEMBL6089196 0.91 SIRT1 (0.46) SIRT1MAOBCYP2A6AMY1AMAPT
SCHEMBL6091571 0.89 SIRT1 (0.42) SIRT1MAOBCYP2A6CDK5CDK5R1
SCHEMBL6089019 0.88 SIRT1 (0.40) SIRT1MAOBCYP2A6AMY1AGRIN2D
SCHEMBL6091156 0.86 SIRT1 (0.40) SIRT1MAOBCYP2A6MAPTIDO1
SCHEMBL6090148 0.84 PRF1 (0.38) MAOBMAPTRAB9ASMN1; SMN2NPC1
SCHEMBL6090153 0.84 PRF1 (0.38) MAOBMAPTRAB9ASMN1; SMN2NPC1
SCHEMBL6091179 0.83 SMN1; SMN2 (0.38) SIRT1MAPTRAB9ASMN1; SMN2NPC1
SCHEMBL6091278 0.78 PDPK1 (0.45) CDK5ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1218373-A2 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2002-07-03 EP claimed
WO-2001009121-A2 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2001-02-08 WO claimed
US-7060822-B1 2-pyrazolin-5-ones ABBOTT GMBH & CO. KG (DE) 2006-06-13 US disclosed
EP-1218373-A2 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2002-07-03 EP disclosed
WO-2001009121-A2 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2001-02-08 WO disclosed