Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | F12 | P00748 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PI4KA | P42356 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.32 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8221653 | 0.88 | CCR1 (0.42) | SYKADORA2AADORA1KDM4EALOX15 | |
| SCHEMBL8222632 | 0.88 | ADORA2A (0.35) | SYKF12PLAUNCF1NOS3 | |
| SCHEMBL8218589 | 0.77 | KDM4E (0.49) | ADORA2AKDM4EALOX15TDP1ALDH1A1 | |
| SCHEMBL8219623 | 0.76 | CCR1 (0.42) | ADORA2AADORA1KDM4EALOX15L3MBTL1 | |
| SCHEMBL11369093 | 0.74 | CLK1 (0.45) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL11377736 | 0.74 | KDM4E (0.51) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL6091929 | 0.73 | ADORA2A (0.38) | SYKF12PLAUNCF1NOS3 | |
| SCHEMBL1754177 | 0.71 | KDM4E (0.42) | NCF1NOS3NOS1NOS2KDM4E | |
| SCHEMBL1384661 | 0.71 | NOS3 (0.53) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL11372368 | 0.70 | SYK (0.60) | SYKF12PLAUNCF1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188120-B2 | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-05-29 | — | — | US | disclosed |
| US-7005435-B2 | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2006-02-28 | — | — | US | disclosed |