Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 3/20 | 0.42 |
| ▸ | CCR5 | P51681 | 3/20 | 0.42 |
| ▸ | CCR8 | P51685 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | METAP1 | P53582 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8221653 | 0.88 | CCR1 (0.42) | CCR1CCR5CCR8KDM4EALDH1A1 | |
| SCHEMBL8222632 | 0.88 | ADORA2A (0.35) | KDM4EALDH1A1HPGDSMN1; SMN2GLA | |
| SCHEMBL10389484 | 0.81 | ADORA3 (0.55) | CCR1CCR5CCR8KDM4EALDH1A1 | |
| SCHEMBL11371057 | 0.79 | KDM4E (0.49) | CCR1CCR5CCR8KDM4EALDH1A1 | |
| SCHEMBL6090464 | 0.76 | SYK (0.36) | KDM4EALDH1A1HPGDSMN1; SMN2GLA | |
| SCHEMBL8219421 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2GLA | |
| SCHEMBL11381433 | 0.73 | SYK (0.58) | CCR1CCR5CCR8KDM4EALDH1A1 | |
| SCHEMBL11367963 | 0.73 | CCR1 (0.45) | CCR1CCR5CCR8KDM4EALDH1A1 | |
| SCHEMBL11367019 | 0.72 | ADORA3 (0.50) | CCR1CCR5CCR8KDM4EALDH1A1 | |
| SCHEMBL11361335 | 0.72 | ADORA3 (0.50) | CCR1CCR5CCR8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188120-B2 | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-05-29 | — | — | US | disclosed |