Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 11/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.43 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | CCKAR | P32238 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090615 | 0.88 | HMGCR (0.49) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL6091718 | 0.88 | HMGCR (0.41) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL5731420 | 0.87 | HMGCR (0.45) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL5731592 | 0.86 | HMGCR (0.43) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL6092472 | 0.86 | KDM4E (0.43) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL5731467 | 0.78 | HMGCR (0.52) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL5731834 | 0.76 | HMGCR (0.54) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL6091284 | 0.76 | HMGCR (0.50) | HMGCR | |
| SCHEMBL5732152 | 0.76 | HMGCR (0.56) | HMGCRABCB11 | |
| SCHEMBL5732170 | 0.75 | NPC1 (0.38) | HMGCRCYP2C9SIRT6ABCC3ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006059210-A2 | FUSED BICYCLIC PYRROLS AS HMG-COA REDUCTASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2006-06-08 | — | — | WO | disclosed |