Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.37 |
| ▸ | HMGCR | P04035 | 2/20 | 0.37 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091508 | 0.90 | MEN1 (0.44) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5730836 | 0.88 | ALDH1A1 (0.42) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5731885 | 0.88 | MAPT (0.42) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6090595 | 0.86 | HMGCR (0.43) | KDM4EALDH1A1LMNACYP2C9SIRT6 | |
| SCHEMBL6090615 | 0.81 | HMGCR (0.49) | CYP2C9SIRT6HMGCRABCC3ABCB11 | |
| SCHEMBL6090758 | 0.80 | KDM4E (0.46) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5732032 | 0.79 | MGLL (0.41) | KDM4EMAPTKMT2ALMNACYP2C9 | |
| SCHEMBL6091718 | 0.77 | HMGCR (0.41) | KDM4EALDH1A1LMNACYP2C9SIRT6 | |
| SCHEMBL5731420 | 0.73 | HMGCR (0.45) | KDM4EALDH1A1LMNACYP2C9SIRT6 | |
| SCHEMBL6091284 | 0.72 | HMGCR (0.50) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006059210-A2 | FUSED BICYCLIC PYRROLS AS HMG-COA REDUCTASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2006-06-08 | — | — | WO | disclosed |