Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27889697 | 0.82 | ERN1 (0.57) | ERN1HPGDGAAL3MBTL1ALDH1A1 | |
| SCHEMBL30400094 | 0.82 | ORAI1 (0.48) | ERN1HPGDL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL6087632 | 0.82 | ORAI1 (0.48) | ERN1HPGDL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL30973586 | 0.81 | ERN1 (0.55) | ERN1HPGDGAAL3MBTL1ALDH1A1 | |
| SCHEMBL1748175 | 0.80 | ERN1 (0.66) | ERN1HPGDGAAL3MBTL1ALDH1A1 | |
| SCHEMBL17221402 | 0.79 | POLB (0.39) | ERN1HPGDALDH1A1HTTPOLB | |
| SCHEMBL5883425 | 0.77 | KDM4E (0.66) | ERN1HPGDGAAL3MBTL1ALDH1A1 | |
| SCHEMBL11124687 | 0.77 | ALDH1A1 (0.43) | GAAL3MBTL1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL12515887 | 0.77 | ALDH1A1 (0.55) | ERN1HPGDL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL4435362 | 0.76 | ERN1 (0.54) | ERN1HPGDGAAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |