SCHEMBL60909

SCHEMBL60909

NC(O)(Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
BLM P54132 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
HIF1A Q16665 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL60910 1.00 BLM (0.31) BLMSMN1; SMN2HIF1A
D-Histidine SCHEMBL15663595 0.87 SLC7A5 (0.38) BLMHIF1A
SCHEMBL1331226 0.84 BLM (0.32) BLMSMN1; SMN2HIF1A
SCHEMBL3510446 0.84 BLM (0.32) BLMSMN1; SMN2HIF1A
SCHEMBL3291889 0.83 HRH4 (0.32) BLMSMN1; SMN2HIF1A
SCHEMBL59405 0.81 BLM (0.47) BLMSMN1; SMN2HIF1A
SCHEMBL163221 0.81 BLM (0.47) BLMSMN1; SMN2HIF1A
SCHEMBL26913087 0.81 BLM (0.30) BLMSMN1; SMN2HIF1A
SCHEMBL10713853 0.81 BLM (0.30) BLMSMN1; SMN2HIF1A
SCHEMBL59406 0.81 BLM (0.47) BLMSMN1; SMN2HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 190 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3250191-B1 TABLETS COMPRISING GLP-1 AGONIST AND ENTERIC COATING NOVO NORDISK AS (DK) 2024-01-17 EP claimed
EP-2637698-B1 DOUBLE-ACYLATED GLP-1 DERIVATIVES NOVO NORDISK AS (DK) 2022-04-20 EP claimed
CN-107205948-B Tablets comprising a GLP-1 agonist and an enteric coating 诺和诺德股份有限公司 2021-12-14 CN claimed
US-11117947-B2 Double-acylated GLP-1 derivatives NOVO NORDISK A/S (DK) 2021-09-14 US claimed
US-11034746-B2 Double-acylated GLP-1 derivatives NOVO NORDISK A/S (DK) 2021-06-15 US claimed
US-10604554-B2 Double-acylated GLP-1 derivatives NOVO NORDISK A/S (DK) 2020-03-31 US claimed
US-20200079834-A1 DOUBLE-ACYLATED GLP-1 DERIVATIVES NOVO NORDISK AS (DK) 2020-03-12 US claimed
US-10308700-B2 GLP-1 derivatives NOVO NORDISK A/S (DK) 2019-06-04 US claimed
US-10265384-B2 Tablets comprising GLP-1 agonist and enteric coating NOVO NORDISK A/S (DK) 2019-04-23 US claimed
EP-3225631-B1 DOUBLE-ACYLATED GLP-1 DERIVATIVES NOVO NORDISK AS (DK) 2019-01-09 EP claimed
US-7893017-B2 Acylation; point mutations; site-directed mutagenesis; hyperglycemia; diabetes NOVO NORDISK A/S (DK) 2011-02-22 US claimed
EP-1863839-B1 ACYLATED GLP-1 COMPOUNDS NOVO NORDISK AS (DK) 2010-08-04 EP claimed
US-20090156478-A1 Acylated GLP-1 Compounds NOVO NORDISK A/S (DK) 2009-06-18 US claimed
US-20080207507-A1 Extended Glp-1 Compounds NOVO NORDISK A/S (DK) 2008-08-28 US claimed
CN-101133082-A Acylated GLP-1 compounds NOVO NORDISK AS (DK) 2008-02-27 CN claimed
CN-101128214-A Extended GLP-1 compounds NOVO NORDISK AS (DK) 2008-02-20 CN claimed
EP-1863521-A1 EXTENDED GLP-1 COMPOUNDS Novo Nordisk A/S (DK) 2007-12-12 EP claimed
EP-1863839-A2 ACYLATED GLP-1 COMPOUNDS NOVO NORDISK A/S (DK) 2007-12-12 EP claimed
WO-2006097538-A1 EXTENDED GLP-1 COMPOUNDS NOVO NORDISK A/S (DK) 2006-09-21 WO claimed
WO-2006097537-A2 ACYLATED GLP-1 COMPOUNDS NOVO NORDISK A/S (DK) 2006-09-21 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080207507-A1 Extended Glp-1 Compounds GLP1R, GIPR, IAPP BLM 2791/4885SMN1; SMN2 1213/4885HIF1A 2586/4885
US-20090156478-A1 Acylated GLP-1 Compounds GLP1R, GIPR, GCGR BLM 4498/4885SMN1; SMN2 2903/4885HIF1A 3023/4885
US-10604554-B2 Double-acylated GLP-1 derivatives GLP1R, GIPR, GPR119 BLM 4665/4885SMN1; SMN2 3591/4885HIF1A 973/4885
US-10308700-B2 GLP-1 derivatives GLP1R, GIPR, GCG BLM 4041/4885SMN1; SMN2 4310/4885HIF1A 524/4885
US-11117947-B2 Double-acylated GLP-1 derivatives GLP1R, SLC5A1, IAPP BLM 4807/4885SMN1; SMN2 4151/4885HIF1A 1028/4885
US-10265384-B2 Tablets comprising GLP-1 agonist and enteric coating GLP1R, GIPR, SLC10A2 BLM 4733/4885SMN1; SMN2 1133/4885HIF1A 4386/4885
US-11034746-B2 Double-acylated GLP-1 derivatives GLP1R, SLC5A1, IAPP BLM 4814/4885SMN1; SMN2 4071/4885HIF1A 1038/4885
US-20200079834-A1 DOUBLE-ACYLATED GLP-1 DERIVATIVES GLP1R, SLC5A1, IAPP BLM 4807/4885SMN1; SMN2 4151/4885HIF1A 1028/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.