Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.58 |
| ▸ | FABP4 | P15090 | 3/20 | 0.50 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.50 |
| ▸ | FABP3 | P05413 | 1/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 3/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089531 | 0.85 | KDM4E (0.59) | TBXAS1PTGDR2ALDH1A1KDM4EMAPT | |
| SCHEMBL28836992 | 0.77 | CREBBP (0.66) | CREBBPFABP4FABP5FABP3TBXAS1 | |
| SCHEMBL8527863 | 0.76 | CREBBP (0.64) | CREBBPFABP4FABP5FABP3TBXAS1 | |
| SCHEMBL6866591 | 0.76 | CREBBP (0.68) | CREBBPFABP4FABP5FABP3TBXAS1 | |
| SCHEMBL2554994 | 0.74 | CREBBP (1.00) | CREBBPFABP4FABP5FABP3ALDH1A1 | |
| SCHEMBL1249875 | 0.74 | CREBBP (0.61) | CREBBPFABP4FABP5FABP3TBXAS1 | |
| SCHEMBL19237507 | 0.72 | CREBBP (0.63) | CREBBPFABP4FABP5FABP3TBXAS1 | |
| SCHEMBL3592270 | 0.72 | GLA (0.54) | CREBBPTBXAS1MCL1CDC25AALDH1A1 | |
| SCHEMBL6091661 | 0.71 | ALDH1A1 (0.64) | TBXAS1PTGDR2ALDH1A1KDM4EMAPT | |
| SCHEMBL12194245 | 0.70 | ALDH1A1 (0.75) | CREBBPFABP4FABP5FABP3TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235222-A1 | Indole-derivative modulators of steroid hormone nuclear receptors | ELI LILLY AND COMPANY (US) | 2006-10-19 | — | — | US | disclosed |
| CN-1742007-A | Indole-derivative modulators of steroid hormone nuclear receptors | LILLY CO ELI (US) | 2006-03-01 | — | — | CN | disclosed |
| EP-1597254-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | Eli Lilly and Company (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004067529-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-08-12 | — | — | WO | disclosed |
| WO-2004067529-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235222-A1 | Indole-derivative modulators of steroid hormone nuclear receptors | NR3C2, NR5A1, MC2R | CREBBP 528/4885FABP4 503/4885FABP5 494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.