Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 13/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 9/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089447 | 0.86 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL6088757 | 0.78 | CYSLTR1 (0.48) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL6089021 | 0.77 | CYSLTR1 (0.48) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL6089420 | 0.76 | CYSLTR1 (0.47) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL6089083 | 0.75 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL6088400 | 0.73 | CYSLTR1 (0.62) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL6092289 | 0.73 | ALOX5 (0.58) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL6089840 | 0.73 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL6088592 | 0.73 | CYSLTR1 (0.48) | CYSLTR1CYSLTR2ALOX5GPBAR1MAPT | |
| SCHEMBL6089416 | 0.72 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2GPBAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |