SCHEMBL6091147

SCHEMBL6091147

CC(C1=NNC(=O)/C1=C/c1cc2ccccc2[nH]1)c1ccc(C(=O)O)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT1 Q96EB6 1/20 0.40
KAT8 Q9H7Z6 1/20 0.35
CYP2A6 P11509 1/20 0.35
PRF1 P14222 1/20 0.35
KDM4E B2RXH2 3/20 0.34
MAPT P10636 1/20 0.34
DAO P14920 1/20 0.34
HPGD P15428 1/20 0.34
SRD5A2 P31213 1/20 0.34
HSD17B10 Q99714 1/20 0.34
MAOB P27338 2/20 0.34
MLKL Q8NB16 2/20 0.34
PHGDH O43175 1/20 0.34
EGFR P00533 1/20 0.33
PIK3CA P42336 1/20 0.33
TSHR P16473 1/20 0.33
KDR P35968 1/20 0.33
PIM1 P11309 1/20 0.33
ATP6V1B1 P15313 1/20 0.33
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6089015 0.91 SIRT1 (0.39) SIRT1CYP2A6PRF1KDM4EMAOB
SCHEMBL6091175 0.89 PDE2A (0.38) SIRT1KDM4EMAPTHPGDHSD17B10
SCHEMBL6091569 0.89 SIRT1 (0.42) SIRT1CYP2A6PRF1KDM4EMAPT
SCHEMBL6090352 0.87 SIRT1 (0.42) SIRT1CYP2A6PRF1MAPTMAOB
SCHEMBL6091156 0.77 SIRT1 (0.40) SIRT1KAT8CYP2A6PRF1KDM4E
SCHEMBL6089672 0.74 SIRT1 (0.46) SIRT1CYP2A6PRF1KDM4EMAPT
SCHEMBL6089676 0.74 SIRT1 (0.46) SIRT1CYP2A6PRF1KDM4EMAPT
SCHEMBL6089777 0.73 KDR (0.55) SIRT1CYP2A6PRF1KDM4EMAPT
SCHEMBL6089770 0.73 KDR (0.55) SIRT1CYP2A6PRF1KDM4EMAPT
SCHEMBL6088344 0.72 SIRT1 (0.46) SIRT1CYP2A6PRF1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1218373-A2 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2002-07-03 EP claimed
WO-2001009121-A2 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2001-02-08 WO claimed
US-7060822-B1 2-pyrazolin-5-ones ABBOTT GMBH & CO. KG (DE) 2006-06-13 US disclosed
EP-1218373-A2 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2002-07-03 EP disclosed
WO-2001009121-A2 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2001-02-08 WO disclosed