Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.58 |
| ▸ | DRD2 | P14416 | 7/20 | 0.58 |
| ▸ | HTR2A | P28223 | 7/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6102727 | 0.88 | HTR1A (0.56) | HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL6091955 | 0.87 | HTR1A (0.44) | HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL4757893 | 0.86 | DRD2 (0.70) | HTR1ADRD2HTR2ASLC6A4KCNH2 | |
| SCHEMBL6101800 | 0.82 | HTR1A (0.56) | HTR1ADRD2HTR2ASLC6A4KCNH2 | |
| SCHEMBL5372211 | 0.78 | HTR1A (0.75) | HTR1ADRD2HTR2ASLC6A4KCNH2 | |
| SCHEMBL6102378 | 0.77 | DRD2 (0.58) | HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL6105551 | 0.76 | HTR1A (0.55) | HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL6103440 | 0.76 | DRD2 (0.61) | HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL5373960 | 0.76 | DRD2 (0.72) | HTR1ADRD2HTR2ASLC6A4KCNH2 | |
| SCHEMBL5366589 | 0.75 | DRD2 (0.68) | HTR1ADRD2HTR2ASLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006090272-A1 | ISOQUINOLINE [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2006-08-31 | — | — | WO | claimed |
| WO-2006090272-A1 | ISOQUINOLINE [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2006-08-31 | — | — | WO | disclosed |