Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ERN1 | O75460 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14560414 | 0.87 | HTR2A (0.49) | ALDH1A1KMT2AMEN1ERN1MAPT | |
| SCHEMBL18886833 | 0.77 | HSD17B10 (0.70) | ALDH1A1KMT2AMEN1MAPTALOX15 | |
| SCHEMBL31025920 | 0.77 | HSD17B10 (0.70) | ALDH1A1KMT2AMEN1MAPTALOX15 | |
| SCHEMBL14280374 | 0.74 | KMT2A (1.00) | ALDH1A1KMT2AMEN1ERN1MAPT | |
| SCHEMBL29422865 | 0.74 | KMT2A (1.00) | ALDH1A1KMT2AMEN1ERN1MAPT | |
| SCHEMBL3282288 | 0.72 | ALDH1A1 (0.60) | ALDH1A1MAPTALOX15TSHRKDM4E | |
| SCHEMBL29637659 | 0.71 | MAPT (0.43) | ALDH1A1MAPTTSHRKDM4EHPGD | |
| SCHEMBL29956788 | 0.71 | HTT (0.51) | ALDH1A1MAPTTSHRKDM4EHPGD | |
| SCHEMBL7380422 | 0.71 | HTT (0.51) | ALDH1A1MAPTTSHRKDM4EHPGD | |
| SCHEMBL18886849 | 0.70 | ALDH1A1 (0.53) | ALDH1A1KMT2AMEN1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |