Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29956788 | 1.00 | HTT (0.51) | HTTMAPTHKDC1NPSR1ALDH1A1 | |
| SCHEMBL28804680 | 0.86 | RAB9A (0.54) | HTTMAPTHKDC1NPSR1ALDH1A1 | |
| SCHEMBL29836517 | 0.82 | KDM4E (0.56) | HTTMAPTALDH1A1KDM4EGAA | |
| SCHEMBL29637659 | 0.82 | MAPT (0.43) | HTTMAPTHKDC1NPSR1ALDH1A1 | |
| SCHEMBL14950314 | 0.82 | HTT (0.47) | HTTMAPTALDH1A1KDM4EGAA | |
| SCHEMBL29951907 | 0.81 | MAPT (0.63) | HTTMAPTHKDC1NPSR1ALDH1A1 | |
| SCHEMBL29836560 | 0.81 | KDM4E (0.57) | MAPTALDH1A1KDM4EGAACYP3A4 | |
| SCHEMBL28946929 | 0.81 | KDM4E (0.57) | MAPTALDH1A1KDM4EGAACYP3A4 | |
| SCHEMBL7373958 | 0.81 | ALDH1A1 (0.54) | MAPTHKDC1NPSR1ALDH1A1KDM4E | |
| SCHEMBL14092334 | 0.81 | HTT (0.46) | HTTMAPTALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1141295-C | Indoline derivatives as progesterohe antagonists | �Ʒ� | 2004-03-10 | — | — | CN | disclosed |
| CN-1350523-A | Indoline derivatives as progesterone antagonists | AMERICAN HOME PROD (US) | 2002-05-22 | — | — | CN | disclosed |
| CN-1349416-A | Contraceptive compositions contaiing indoline derivatives and progestational agents | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | disclosed |
| EP-0420086-B1 | Pyrimidoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-12-13 | — | — | EP | disclosed |
| US-5256780-A | Serotonin antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-26 | — | — | US | disclosed |
| US-5180728-A | Antagonists of 5-hydroxytryptamine | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1993-01-19 | — | — | US | disclosed |
| EP-0420086-A2 | Pyrimidoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-03 | — | — | EP | disclosed |