Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ofloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 1.00 |
| ▸ | TUBB4A | P04350 | 7/20 | 1.00 |
| ▸ | TUBB | P07437 | 7/20 | 1.00 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 1.00 |
| ▸ | TUBA1B | P68363 | 7/20 | 1.00 |
| ▸ | TUBA4A | P68366 | 7/20 | 1.00 |
| ▸ | TUBB4B | P68371 | 7/20 | 1.00 |
| ▸ | TUBB3 | Q13509 | 7/20 | 1.00 |
| ▸ | TUBB2A | Q13885 | 7/20 | 1.00 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 1.00 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 1.00 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 1.00 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 1.00 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 1.00 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 1.00 |
| ▸ | TUBB1 | Q9H4B7 | 7/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 1.00 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ofloxacin SCHEMBL6090650 | 1.00 | KDM4E (1.00) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| Levofloxacin Anhydrous SCHEMBL891190 | 1.00 | KDM4E (1.00) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| Levofloxacin Anhydrous SCHEMBL1650602 | 1.00 | KDM4E (1.00) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| Levofloxacin Anhydrous SCHEMBL30009030 | 1.00 | KDM4E (1.00) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| Levofloxacin Anhydrous SCHEMBL27810870 | 0.99 | KDM4E (0.98) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| Ofloxacin SCHEMBL9745243 | 0.99 | KDM4E (1.00) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| Dextrofloxacine SCHEMBL4316947 | 0.99 | KDM4E (1.00) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| Ofloxacin SCHEMBL14163982 | 0.99 | KDM4E (1.00) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| Ofloxacin SCHEMBL5532921 | 0.99 | KDM4E (1.00) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| Ofloxacin SCHEMBL24373 | 0.99 | KDM4E (1.00) | KDM4ETUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107434810-A | A kind of levofloxacin impurity and preparation method thereof | 浙江京新药业股份有限公司 | 2017-12-05 | — | — | CN | claimed |
| WO-2006009374-A1 | PROCESS FOR PREPARING LEVOFLOXACIN OR ITS HYDRATE | YUHAN CORPORATION (KR) | 2006-01-26 | — | — | WO | disclosed |
| US-5023257-A | Related to ciprofloxacin, in the form of oily suspension; bacterial infections | BAYER AKTIENGESELLSCHAFT (DE) | 1991-06-11 | — | — | US | disclosed |
| CN-1037272-A | The intramuscular injection agent of gyrase inhibitor | BAYER AG (DE) | 1989-11-22 | — | — | CN | disclosed |