Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.45 |
| ▸ | MEN1 | O00255 | 8/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 4/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092285 | 1.00 | KMT2A (0.45) | KMT2AMEN1POLBKDRDHFR | |
| SCHEMBL6090331 | 0.90 | KMT2A (0.45) | KMT2AMEN1POLBKDRDHFR | |
| SCHEMBL6090339 | 0.90 | KMT2A (0.45) | KMT2AMEN1POLBKDRDHFR | |
| SCHEMBL6090511 | 0.87 | KMT2A (0.48) | KMT2AMEN1POLBKDRDHFR | |
| SCHEMBL6090516 | 0.87 | KMT2A (0.48) | KMT2AMEN1POLBKDRDHFR | |
| SCHEMBL6091988 | 0.84 | KMT2A (0.60) | KMT2AMEN1KDRCRHBPCRHR2 | |
| SCHEMBL6091982 | 0.84 | KMT2A (0.60) | KMT2AMEN1KDRCRHBPCRHR2 | |
| SCHEMBL6089202 | 0.82 | DHFR (0.43) | KMT2AMEN1POLBKDRDHFR | |
| SCHEMBL6089206 | 0.82 | DHFR (0.43) | KMT2AMEN1POLBKDRDHFR | |
| SCHEMBL6090246 | 0.81 | KMT2A (0.42) | KMT2AMEN1POLBKDRDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |