Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | DHFR | P00374 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090511 | 1.00 | KMT2A (0.48) | KMT2AMEN1SMN1; SMN2NPSR1S1PR4 | |
| SCHEMBL6092288 | 0.87 | KMT2A (0.45) | KMT2AMEN1POLBKDRDHFR | |
| SCHEMBL6092285 | 0.87 | KMT2A (0.45) | KMT2AMEN1POLBKDRDHFR | |
| SCHEMBL6090331 | 0.85 | KMT2A (0.45) | KMT2AMEN1POLBKDRDHFR | |
| SCHEMBL6090339 | 0.85 | KMT2A (0.45) | KMT2AMEN1POLBKDRDHFR | |
| SCHEMBL6089202 | 0.84 | DHFR (0.43) | KMT2AMEN1POLBKDRDHFR | |
| SCHEMBL6089206 | 0.84 | DHFR (0.43) | KMT2AMEN1POLBKDRDHFR | |
| SCHEMBL6090246 | 0.84 | KMT2A (0.42) | KMT2AMEN1SMN1; SMN2NPSR1L3MBTL1 | |
| SCHEMBL6092911 | 0.84 | SIRT1 (0.46) | KMT2AMEN1SMN1; SMN2POLBKDR | |
| SCHEMBL6090249 | 0.84 | KMT2A (0.42) | KMT2AMEN1SMN1; SMN2NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |