Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089628 | 0.81 | CYSLTR1 (0.37) | PTGDR2CYSLTR1GPBAR1CYP1A2CYSLTR2 | |
| SCHEMBL6092671 | 0.77 | CYSLTR1 (0.39) | PTGDR2CYSLTR1GPBAR1CYP1A2CYSLTR2 | |
| SCHEMBL6088877 | 0.69 | CYP1A2 (0.36) | PTGDR2CYSLTR1GPBAR1CYP1A2CYSLTR2 | |
| SCHEMBL6089639 | 0.67 | CYSLTR1 (0.41) | PTGDR2CYSLTR1GPBAR1CYP1A2CYSLTR2 | |
| SCHEMBL6090578 | 0.66 | CYSLTR1 (0.58) | CYSLTR1GPBAR1CYP1A2CYSLTR2 | |
| SCHEMBL6089436 | 0.65 | CYP11B1 (0.45) | PTGDR2CYSLTR1GPBAR1CYP1A2FAAH | |
| SCHEMBL6089645 | 0.65 | CYSLTR1 (0.39) | CYSLTR1GPBAR1CYP1A2CYSLTR2 | |
| SCHEMBL4841446 | 0.64 | CYSLTR1 (0.47) | CYSLTR1GPBAR1CYP1A2CYSLTR2 | |
| SCHEMBL4848359 | 0.64 | CYSLTR1 (0.50) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10085682 | 0.64 | HDAC3 (0.44) | PTGDR2CYSLTR1GPBAR1CYP1A2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |