Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.37 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.37 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10025494 | 0.82 | TDP1 (0.36) | TDP1TXNRD1TXNRD3TXNRD2TSHR | |
| SCHEMBL3944662 | 0.79 | NPC1 (0.43) | TDP1TSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL27500902 | 0.72 | TSHR (0.42) | TDP1TXNRD1TXNRD3TXNRD2TSHR | |
| SCHEMBL13724379 | 0.67 | MAP3K14 (0.45) | TDP1MAOAALDH1A1POLBKMT2A | |
| SCHEMBL8403300 | 0.66 | TXNRD1 (0.68) | TDP1TXNRD1TXNRD3TXNRD2TSHR | |
| SCHEMBL8403306 | 0.66 | TXNRD1 (0.50) | TDP1TXNRD1TXNRD3TXNRD2TSHR | |
| SCHEMBL8403301 | 0.66 | TDP1 (0.42) | TDP1TXNRD1TXNRD3TXNRD2TSHR | |
| SCHEMBL30503599 | 0.66 | TDP1 (0.71) | TDP1TSHRSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9719281 | 0.66 | TDP1 (0.71) | TDP1TSHRSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL13222350 | 0.63 | TXNRD1 (0.38) | TDP1TXNRD1TXNRD3TXNRD2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7012090-B1 | such as 1-(2-aminopropyl)-3,7,8,9,-tetrahydro-pyrano-[3,2-e]indol-8-ol | ALCON, INC. (CH) | 2006-03-14 | — | — | US | disclosed |
| EP-1268482-B1 | PYRANOINDOLES FOR TREATING GLAUCOMA | ALCON INC (CH) | 2003-09-24 | — | — | EP | disclosed |
| EP-1268482-A1 | PYRANOINDOLES FOR TREATING GLAUCOMA | Alcon Universal, Ltd. (CH) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070745-A1 | PYRANOINDOLES FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-09-27 | — | — | WO | disclosed |