Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.36 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27500902 | 0.78 | TSHR (0.42) | TDP1TSHRSMN1; SMN2TXNRD1TXNRD3 | |
| SCHEMBL8405586 | 0.73 | CYP3A4 (0.33) | TSHRCYP3A4 | |
| SCHEMBL8403306 | 0.69 | TXNRD1 (0.50) | TDP1TSHRSMN1; SMN2TXNRD1TXNRD3 | |
| SCHEMBL8407493 | 0.69 | ALDH1A1 (0.40) | TDP1TSHRSMN1; SMN2CYP3A4NPC1 | |
| SCHEMBL30503599 | 0.69 | TDP1 (0.71) | TDP1TSHRSMN1; SMN2CYP3A4HSD17B10 | |
| SCHEMBL9719281 | 0.69 | TDP1 (0.71) | TDP1TSHRSMN1; SMN2CYP3A4HSD17B10 | |
| SCHEMBL13091607 | 0.67 | TSHR (0.47) | TDP1TSHRSMN1; SMN2CYP3A4NPC1 | |
| SCHEMBL6092680 | 0.66 | TDP1 (0.39) | TDP1TSHRSMN1; SMN2TXNRD1TXNRD3 | |
| SCHEMBL8403300 | 0.66 | TXNRD1 (0.68) | TDP1TSHRSMN1; SMN2TXNRD1TXNRD3 | |
| SCHEMBL10815482 | 0.65 | MAPT (0.47) | TDP1TSHRTXNRD1TXNRD3TXNRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965595-A | SIDE EFFECT REDUCTION; TREATING NASAL CONGESTION AND OTHER ALPHA-2 ADRENORECEPTOR MODULATED DISORDERS, WILL NOT CAUSE HYPERTENSION | THE PROCTER & GAMBLE COMPANY (US) | 1999-10-12 | — | — | US | disclosed |
| US-5914342-A | 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-22 | — | — | US | disclosed |
| US-5663189-A | RESPIRATORY, EYES, GASTROINTESTINAL | THE PROCTER & GAMBLE COMPANY (US) | 1997-09-02 | — | — | US | disclosed |