Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | CCR5 | P51681 | 1/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1888780 | 0.89 | KDM4E (0.74) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL31583128 | 0.88 | MAPT (0.63) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL3156422 | 0.88 | KDM4E (0.73) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL1505913 | 0.88 | ALDH1A1 (0.75) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL608528 | 0.87 | ALDH1A1 (0.76) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL5744006 | 0.87 | KDM4E (1.00) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL6988354 | 0.86 | KDM4E (0.74) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL7438287 | 0.86 | ALDH1A1 (0.74) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL22265730 | 0.86 | KDM4E (0.76) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL12204641 | 0.85 | KDM4E (0.69) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125895-B1 | Cyclic amine derivatives and their uses | BRISTOL-MYERS SQUIBB PHARMA RESEARCH LABS, INC. (US) | 2006-10-24 | — | — | US | disclosed |