Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090425 | 1.00 | KDR (0.53) | KDRCHEK1CDC7DBF4ABL1 | |
| SCHEMBL6089095 | 0.87 | KDR (0.49) | KDRCHEK1 | |
| SCHEMBL6089107 | 0.87 | KDR (0.49) | KDRCHEK1 | |
| SCHEMBL6093367 | 0.84 | ALK (0.41) | KDRCDC7DBF4ABL1RET | |
| SCHEMBL6093374 | 0.84 | ALK (0.41) | KDRCDC7DBF4ABL1RET | |
| SCHEMBL6090612 | 0.84 | KDR (0.61) | KDRCHEK1CDC7DBF4ABL1 | |
| SCHEMBL6090600 | 0.84 | KDR (0.61) | KDRCHEK1CDC7DBF4ABL1 | |
| SCHEMBL6089402 | 0.80 | KDR (0.52) | KDRCHEK1ABL1RETPDGFRB | |
| SCHEMBL6089417 | 0.80 | KDR (0.52) | KDRCHEK1ABL1RETPDGFRB | |
| SCHEMBL6090275 | 0.80 | KDR (0.52) | KDRCHEK1CDC7DBF4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |