Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.41 |
| ▸ | TUBB | P07437 | 2/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6094051 | 0.84 | MAPT (0.45) | ERN1KLKB1KLK1TNFRSF1ACTNNB1 | |
| SCHEMBL6091660 | 0.83 | ERN1 (0.44) | ERN1TNFRSF1AMAPTALDH1A1KDM4E | |
| SCHEMBL6092789 | 0.83 | ERN1 (0.44) | ERN1TNFRSF1AMAPTALDH1A1KDM4E | |
| SCHEMBL6093223 | 0.80 | TNFRSF1A (0.45) | ERN1TNFRSF1AMAPTALDH1A1KDM4E | |
| SCHEMBL6091847 | 0.78 | ABCB1 (0.41) | ERN1TNFRSF1AMAPTALDH1A1HPGD | |
| SCHEMBL6095260 | 0.78 | ERN1 (0.46) | ERN1TNFRSF1AMAPTALDH1A1KDM4E | |
| SCHEMBL6092830 | 0.78 | TNFRSF1A (0.57) | ERN1TNFRSF1AMAPTALDH1A1KDM4E | |
| SCHEMBL6093618 | 0.77 | ERN1 (0.39) | ERN1TNFRSF1AMAPTALDH1A1KDM4E | |
| SCHEMBL6091494 | 0.76 | TNFRSF1A (0.44) | ERN1TNFRSF1AMAPTALDH1A1KDM4E | |
| SCHEMBL6091675 | 0.75 | KDM4E (0.52) | ERN1TNFRSF1ACTNNB1WNT3AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ATHEROGENICS, INC. | 2006-03-23 | — | — | US | claimed |
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ATHEROGENICS, INC. | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ABCB11, CEL, CYP46A1 | ERN1 2367/4885KLKB1 1505/4885KLK1 1134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.