Sugi Predict

Sugi Predict / Compounds / SCHEMBL6094420

SCHEMBL6094420

SCHEMBL6094420

OC(C(O)n1cnc2ccccc21)n1cnc2ccccc21

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 2/20 0.58
▸ MEN1 O00255 1/20 0.58
▸ HPGD P15428 1/20 0.58
▸ KMT2A Q03164 1/20 0.58
▸ LMNA P02545 2/20 0.49
▸ SMN1; SMN2 Q16637 2/20 0.49
▸ STAT6 P42226 1/20 0.49
▸ TDP1 Q9NUW8 1/20 0.48
▸ HDAC8 Q9BY41 1/20 0.48
▸ AGER Q15109 4/20 0.47
▸ HTT P42858 2/20 0.47
▸ FGFR1 P11362 2/20 0.46
▸ GGPS1 O95749 1/20 0.44
▸ FDPS P14324 1/20 0.44
▸ POLB P06746 2/20 0.43
▸ MAPT P10636 2/20 0.43
▸ MAPK1 P28482 2/20 0.43
▸ TSHR P16473 1/20 0.43
▸ TNF P01375 1/20 0.43
▸ CYP11B1 P15538 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4070928 0.89 MEN1 (0.60) HSD17B10MEN1HPGDKMT2ALMNA
SCHEMBL7514337 0.88 HSD17B10 (0.58) HSD17B10MEN1HPGDKMT2ALMNA
SCHEMBL9754107 0.84 HSD17B10 (0.54) HSD17B10MEN1HPGDKMT2ALMNA
SCHEMBL250816 0.84 MEN1 (0.64) HSD17B10MEN1HPGDKMT2ALMNA
SCHEMBL4087403 0.83 HDAC8 (0.59) HSD17B10MEN1HPGDKMT2ALMNA
SCHEMBL16504441 0.82 HSD17B10 (0.57) HSD17B10MEN1HPGDKMT2ALMNA
SCHEMBL6174314 0.81 MEN1 (0.60) HSD17B10MEN1HPGDKMT2ALMNA
SCHEMBL6284930 0.81 MEN1 (0.60) HSD17B10MEN1HPGDKMT2ALMNA
SCHEMBL8615932 0.81 HSD17B10 (0.65) HSD17B10MEN1HPGDKMT2ALMNA
SCHEMBL5884242 0.80 HSD17B10 (0.50) HSD17B10MEN1HPGDKMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060142365-A1 Benzimidazole compounds and antiviral uses thereof TRIMERIS, INC. 2006-06-29 — — US disclosed
US-7030150-B2 Benzimidazole compounds and antiviral uses thereof TRIMERIS, INC. 2006-04-18 — — US disclosed
US-20040166137-A1 Hetero-substituted benzimidazole compounds and antiviral uses thereof TRIMERIS, INC. 2004-08-26 — — US disclosed
WO-2004043913-A2 HETERO-SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND ANTIVIRAL USES THEREOF TRIMERIS, INC. (US) 2004-05-27 — — WO disclosed
US-20030119754-A1 Benzimidazole compounds and antiviral uses thereof TRIMERIS, INC. 2003-06-26 — — US disclosed
WO-2002092575-A1 BENZIMIDAZOLE COMPOUNDS AND ANTIVIRAL USES THEREOF TRIMERIS, INC. (US) 2002-11-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060142365-A1 Benzimidazole compounds and antiviral uses thereof MAVS, ZC3HAV1, TIMM13 HSD17B10 4029/4885MEN1 4444/4885HPGD 4400/4885
US-20030119754-A1 Benzimidazole compounds and antiviral uses thereof MAVS, ZC3HAV1, TIMM13 HSD17B10 4029/4885MEN1 4444/4885HPGD 4400/4885
US-20040166137-A1 Hetero-substituted benzimidazole compounds and antiviral uses thereof MAVS, TIMM13, TIMM10 HSD17B10 3515/4885MEN1 4683/4885HPGD 4049/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.