Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | GPR183 | P32249 | 1/20 | 0.47 |
| ▸ | GHSR | Q92847 | 3/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | FASN | P49327 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | NUDT15 | Q9NV35 | 1/20 | 0.43 |
| ▸ | OXTR | P30559 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5925669 | 0.93 | GHSR (0.56) | MAPK14GHSR | |
| SCHEMBL6096167 | 0.82 | MAPK14 (0.52) | MAPK14DRD2DRD3GPR183GHSR | |
| SCHEMBL2219560 | 0.82 | MAPK14 (0.60) | MAPK14DRD2DRD3GPR183GHSR | |
| SCHEMBL6094161 | 0.81 | MAPK14 (0.50) | MAPK14DRD2DRD3GPR183GHSR | |
| SCHEMBL6093818 | 0.79 | MAPK14 (0.57) | MAPK14DRD2DRD3GPR183GHSR | |
| SCHEMBL3039407 | 0.78 | MAPK14 (0.64) | MAPK14DRD2DRD3GPR183GHSR | |
| SCHEMBL6094630 | 0.78 | MAPK14 (0.52) | MAPK14MGLLCHRM2 | |
| SCHEMBL6094758 | 0.78 | ALDH1A1 (0.43) | — | |
| SCHEMBL6094856 | 0.78 | MAPK14 (0.51) | MAPK14DRD2DRD3GPR183GHSR | |
| SCHEMBL6097939 | 0.77 | MAPT (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084143-B2 | N-(indolecarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2006-08-01 | — | — | US | claimed |
| US-7084143-B2 | N-(indolecarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2006-08-01 | — | — | US | disclosed |
| US-6838461-B1 | N-(indolcarbonyl-)piperazine derivatives | MERCK PATENT GMBH (DE) | 2005-01-04 | — | — | US | disclosed |
| EP-1198453-B9 | N-(INDOLCARBONYL-)PIPERAZIN DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-11-10 | — | — | EP | disclosed |
| EP-1198453-B1 | N-(INDOLCARBONYL-)PIPERAZIN DERIVATIVES | MERCK PATENT GMBH (DE) | 2003-04-09 | — | — | EP | disclosed |