Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6093813 | 0.86 | HTR2A (0.43) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL6096607 | 0.84 | HTR2A (0.42) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL6095452 | 0.82 | GAA (0.57) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL6094555 | 0.81 | HSP90AA1 (0.45) | GAAKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6095470 | 0.80 | HTR2A (0.46) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL5276390 | 0.79 | HTR2A (0.63) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL5273574 | 0.79 | MAPK14 (0.41) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL5280616 | 0.79 | HTR2A (0.67) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL6094928 | 0.78 | ALDH1A1 (0.40) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL6096013 | 0.78 | PARP1 (0.41) | GAAKDM4EALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084143-B2 | N-(indolecarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2006-08-01 | — | — | US | disclosed |
| EP-1198453-B9 | N-(INDOLCARBONYL-)PIPERAZIN DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-11-10 | — | — | EP | disclosed |
| EP-1198453-B1 | N-(INDOLCARBONYL-)PIPERAZIN DERIVATIVES | MERCK PATENT GMBH (DE) | 2003-04-09 | — | — | EP | disclosed |