Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 2/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3938236 | 0.84 | SRD5A1 (0.50) | SRD5A1PTGS1ALDH1A1GAAALOX5 | |
| SCHEMBL6093774 | 0.79 | SRD5A1 (0.43) | SRD5A1ALDH1A1KDM4ETDP1KMT2A | |
| SCHEMBL31571894 | 0.76 | ALDH1A1 (0.48) | ALDH1A1GAAKDM4ETDP1KMT2A | |
| SCHEMBL31571840 | 0.76 | ALDH1A1 (0.46) | ALDH1A1GAAKDM4ETDP1KMT2A | |
| SCHEMBL28248424 | 0.76 | SRD5A1 (0.52) | SRD5A1PTGS1ALDH1A1GAAALOX5 | |
| SCHEMBL27658679 | 0.76 | ALDH1A1 (0.46) | ALDH1A1GAATDP1KMT2AVCP | |
| SCHEMBL47790 | 0.73 | TSHR (0.42) | ALDH1A1GAAKDM4ETDP1KMT2A | |
| SCHEMBL47791 | 0.73 | TSHR (0.42) | ALDH1A1GAAKDM4ETDP1KMT2A | |
| SCHEMBL10536230 | 0.73 | PTGS1 (0.62) | SRD5A1PTGS1ALDH1A1ALOX5KDM4E | |
| SCHEMBL795687 | 0.72 | KDM4E (0.43) | SRD5A1ALDH1A1KDM4ETDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7012090-B1 | such as 1-(2-aminopropyl)-3,7,8,9,-tetrahydro-pyrano-[3,2-e]indol-8-ol | ALCON, INC. (CH) | 2006-03-14 | — | — | US | disclosed |
| CN-1203072-C | Pyranoindoles for the treatment of glaucoma | ALCON AG (CH) | 2005-05-25 | — | — | CN | disclosed |
| CN-1451008-A | Pyranoindoles for treating alaucoma | ALCON AG (CH) | 2003-10-22 | — | — | CN | disclosed |
| EP-1268482-B1 | PYRANOINDOLES FOR TREATING GLAUCOMA | ALCON INC (CH) | 2003-09-24 | — | — | EP | disclosed |
| EP-1268482-A1 | PYRANOINDOLES FOR TREATING GLAUCOMA | Alcon Universal, Ltd. (CH) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070745-A1 | PYRANOINDOLES FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-09-27 | — | — | WO | disclosed |