Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CTSH | P09668 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7172390 | 0.83 | GPR35 (0.46) | SRD5A1TDP1TSHRHPGDSMN1; SMN2 | |
| SCHEMBL4358720 | 0.81 | ALDH5A1 (0.44) | SRD5A1TDP1TSHRHPGDSMN1; SMN2 | |
| SCHEMBL6094640 | 0.79 | SRD5A1 (0.53) | SRD5A1TDP1TSHRHPGDSMN1; SMN2 | |
| SCHEMBL428326 | 0.78 | GPR35 (0.42) | TDP1TSHRCYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL3258910 | 0.78 | GPR35 (0.51) | SRD5A1TDP1TSHRHPGDSMN1; SMN2 | |
| SCHEMBL10010839 | 0.77 | SRD5A1 (0.46) | SRD5A1HPGDCYP3A4ALDH1A1POLB | |
| SCHEMBL6591933 | 0.74 | SRD5A1 (0.47) | SRD5A1HPGDCYP3A4ALDH1A1POLB | |
| SCHEMBL1896801 | 0.74 | TDP1 (0.56) | TDP1TSHRHPGDSMN1; SMN2CTSB | |
| SCHEMBL11118423 | 0.73 | GABRA1 (0.48) | SRD5A1HPGDCYP3A4ALDH1A1POLB | |
| SCHEMBL11758387 | 0.73 | DTYMK (0.44) | TDP1TSHRCYP3A4ALDH1A1GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7012090-B1 | such as 1-(2-aminopropyl)-3,7,8,9,-tetrahydro-pyrano-[3,2-e]indol-8-ol | ALCON, INC. (CH) | 2006-03-14 | — | — | US | disclosed |
| CN-1203072-C | Pyranoindoles for the treatment of glaucoma | ALCON AG (CH) | 2005-05-25 | — | — | CN | disclosed |
| CN-1451008-A | Pyranoindoles for treating alaucoma | ALCON AG (CH) | 2003-10-22 | — | — | CN | disclosed |
| EP-1268482-B1 | PYRANOINDOLES FOR TREATING GLAUCOMA | ALCON INC (CH) | 2003-09-24 | — | — | EP | disclosed |
| EP-1268482-A1 | PYRANOINDOLES FOR TREATING GLAUCOMA | Alcon Universal, Ltd. (CH) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070745-A1 | PYRANOINDOLES FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-09-27 | — | — | WO | disclosed |