Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 14/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6097974 | 0.86 | HTR7 (0.57) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL6099021 | 0.84 | HTR7 (0.44) | HTR7DRD2HTR1AHTR2AHTR1B | |
| Hydrochloric Acid SCHEMBL6098375 | 0.83 | HTR7 (0.43) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL6096523 | 0.81 | HTR7 (0.44) | HTR7DRD2HTR1AHTR2AHTR1B | |
| Hydrochloric Acid SCHEMBL6096518 | 0.81 | HTR7 (0.43) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL6097277 | 0.71 | HTR7 (0.59) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL6097198 | 0.71 | HTR7 (0.57) | HTR7HTR1AHTR2A | |
| SCHEMBL6096953 | 0.71 | HTR7 (0.42) | HTR7DRD2HTR1AHTR2AKDM4E | |
| Hydrochloric Acid SCHEMBL6094812 | 0.71 | HTR7 (0.44) | HTR7HTR1AHTR2AKDM4E | |
| SCHEMBL6099029 | 0.69 | SMN1; SMN2 (0.41) | HTR7HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | HTR7 1/4885DRD2 74/4885HTR1A 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.