Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.60 |
| ▸ | GHSR | Q92847 | 5/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6094163 | 0.93 | MAPK14 (0.61) | MAPK14GHSRDRD2DRD3HRH4 | |
| SCHEMBL6095301 | 0.84 | MAPK14 (0.79) | MAPK14GHSRDRD2DRD3MEN1 | |
| SCHEMBL5279234 | 0.83 | MAPK14 (0.62) | MAPK14GHSRDRD2DRD3MEN1 | |
| Hydrochloric Acid SCHEMBL27516130 | 0.82 | MAPK14 (0.61) | MAPK14GHSRDRD2DRD3MEN1 | |
| SCHEMBL5279687 | 0.81 | MAPK14 (0.60) | MAPK14GHSRDRD2DRD3HRH4 | |
| SCHEMBL6110669 | 0.79 | GHSR (0.61) | MAPK14GHSRALDH1A1MAPTHSD17B10 | |
| SCHEMBL6094784 | 0.78 | HTR2A (0.45) | MAPK14DRD2DRD3MEN1KMT2A | |
| SCHEMBL5274240 | 0.78 | MAPK14 (0.59) | MAPK14GHSRDRD2DRD3ALDH1A1 | |
| SCHEMBL6096879 | 0.78 | MAPK14 (0.62) | MAPK14DRD2DRD3MEN1KMT2A | |
| SCHEMBL5283296 | 0.78 | MAPK14 (0.59) | MAPK14GHSRDRD2DRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084143-B2 | N-(indolecarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2006-08-01 | — | — | US | claimed |
| US-7084143-B2 | N-(indolecarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2006-08-01 | — | — | US | disclosed |
| WO-2006034788-A1 | COMBINATIONS OF N-(INDOLECARBONYL-)PIPERAZINE DERIVATIVES AND SEROTONIN REUPTAKE INHIBITORS | MERCK PATENT GMBH (DE) | 2006-04-06 | — | — | WO | disclosed |
| CN-1229345-C | N-(indolcarbonyl) piperazin derivatives | MERCK PATENT GMBH (DE) | 2005-11-30 | — | — | CN | disclosed |
| US-6838461-B1 | N-(indolcarbonyl-)piperazine derivatives | MERCK PATENT GMBH (DE) | 2005-01-04 | — | — | US | disclosed |
| EP-1198453-B9 | N-(INDOLCARBONYL-)PIPERAZIN DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-11-10 | — | — | EP | disclosed |
| EP-1198453-B1 | N-(INDOLCARBONYL-)PIPERAZIN DERIVATIVES | MERCK PATENT GMBH (DE) | 2003-04-09 | — | — | EP | disclosed |