Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5280593 | 0.86 | HRH4 (0.58) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL6096879 | 0.83 | MAPK14 (0.62) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL5278050 | 0.83 | HTR2A (0.63) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL6094762 | 0.82 | ALDH1A1 (0.43) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| Hydrochloric Acid SCHEMBL27499109 | 0.82 | HTR2A (0.62) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL6095470 | 0.80 | HTR2A (0.46) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL6093704 | 0.79 | KEAP1 (0.45) | POLBMEN1KMT2AKEAP1PDPK1 | |
| SCHEMBL5273574 | 0.78 | MAPK14 (0.41) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL8291050 | 0.78 | KEAP1 (0.54) | HRH4KMT2AKEAP1PDPK1 | |
| SCHEMBL6097445 | 0.78 | MAPK14 (0.60) | HRH4MAPK14KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084143-B2 | N-(indolecarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2006-08-01 | — | — | US | claimed |
| US-7084143-B2 | N-(indolecarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2006-08-01 | — | — | US | disclosed |
| CN-1229345-C | N-(indolcarbonyl) piperazin derivatives | MERCK PATENT GMBH (DE) | 2005-11-30 | — | — | CN | disclosed |
| US-6838461-B1 | N-(indolcarbonyl-)piperazine derivatives | MERCK PATENT GMBH (DE) | 2005-01-04 | — | — | US | disclosed |
| EP-1198453-B9 | N-(INDOLCARBONYL-)PIPERAZIN DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-11-10 | — | — | EP | disclosed |
| EP-1198453-B1 | N-(INDOLCARBONYL-)PIPERAZIN DERIVATIVES | MERCK PATENT GMBH (DE) | 2003-04-09 | — | — | EP | disclosed |