Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 10/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6098066 | 0.89 | HTR7 (0.42) | HTR7NR1H2NR1H3KMT2ACRHBP | |
| SCHEMBL6097778 | 0.87 | HTR7 (0.43) | HTR7NR1H2NR1H3KMT2A | |
| SCHEMBL6097231 | 0.84 | HTR7 (0.38) | HTR7NR1H2NR1H3KMT2ATRPA1 | |
| SCHEMBL6096984 | 0.82 | HTR7 (0.42) | HTR7NR1H2NR1H3KMT2ATRPA1 | |
| SCHEMBL6098365 | 0.81 | HTR7 (0.40) | HTR7NR1H2NR1H3KMT2ATRPA1 | |
| Hydrochloric Acid SCHEMBL6096973 | 0.81 | HTR7 (0.39) | HTR7NR1H2NR1H3KMT2ATRPA1 | |
| SCHEMBL6096562 | 0.80 | HTR7 (0.38) | HTR7NR1H2NR1H3KMT2ATRPA1 | |
| SCHEMBL6097225 | 0.71 | HTR7 (0.52) | HTR7NR1H2 | |
| SCHEMBL6097772 | 0.71 | HTR7 (0.50) | HTR7NR1H2KMT2AGAA | |
| SCHEMBL6095936 | 0.70 | HTR7 (0.43) | HTR7NR1H2KMT2ACRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | HTR7 1/4885NR1H2 229/4885NR1H3 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.