Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | FPR2 | P25090 | 2/20 | 0.54 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.54 |
| ▸ | LIPE | Q05469 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.49 |
| ▸ | FAAH | O00519 | 2/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6095121 | 0.86 | MMP13 (0.48) | MMP13MMP2FPR2PROKR1LIPE | |
| SCHEMBL6690842 | 0.85 | FPR2 (0.58) | MMP13MMP2FPR2PROKR1EPHX2 | |
| SCHEMBL6518095 | 0.83 | TSHR (0.59) | LIPEEPHX2FFAR4SMN1; SMN2ALDH1A1 | |
| SCHEMBL6095113 | 0.82 | MMP13 (0.51) | MMP13MMP2FPR2PROKR1LIPE | |
| SCHEMBL6094119 | 0.81 | MMP13 (0.57) | MMP13MMP2FPR2PROKR1LIPE | |
| SCHEMBL6098585 | 0.79 | FPR2 (0.64) | MMP13MMP2FPR2PROKR1EPHX2 | |
| SCHEMBL6397014 | 0.79 | MMP13 (0.53) | MMP13MMP2FPR2PROKR1LIPE | |
| SCHEMBL6097817 | 0.78 | EPHX2 (0.56) | MMP13MMP2FPR2PROKR1EPHX2 | |
| SCHEMBL6692336 | 0.76 | MMP13 (0.51) | MMP13MMP2FPR2PROKR1LIPE | |
| SCHEMBL6095581 | 0.75 | MMP13 (0.60) | MMP13MMP2FPR2PROKR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067670-B2 | Sulfamato hydroxamic acid metalloprotease inhibitor | WARNER LAMBERT COMPANY (US) | 2006-06-27 | — | — | US | disclosed |
| US-6800646-B1 | Sulfamato hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION | 2004-10-05 | — | — | US | disclosed |
| US-6492367-B1 | Sulfamato hydroxamic acid metalloprotease inhibitor | G. D. SEARLE & COMPANY | 2002-12-10 | — | — | US | disclosed |
| US-6448250-B1 | INHIBITS THE ACTIVITY OF ONE OR MORE OF THE FOLLOWING MATRIX METALLOPROTEINASES: MMP-2, MMP-9, AND MMP-13, WHILE EXHIBITING SUBSTANTIALLY LESS INHIBITORY ACTIVITY AGAINST MMP-1 | G. D. SEARLE & COMPANY | 2002-09-10 | — | — | US | disclosed |
| EP-1157021-A1 | SULFAMATO HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000046221-A1 | SULFAMATO HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-08-10 | — | — | WO | disclosed |