⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4448430 | 0.89 | — | — | |
| SCHEMBL4529662 | 0.82 | — | — | |
| SCHEMBL198419 | 0.82 | — | — | |
| SCHEMBL4515906 | 0.82 | — | — | |
| SCHEMBL357186 | 0.77 | — | — | |
| SCHEMBL10355207 | 0.75 | — | — | |
| SCHEMBL10221 | 0.75 | — | — | |
| SCHEMBL331996 | 0.73 | GBA1 (0.42) | — | |
| SCHEMBL332080 | 0.73 | GNAO1 (0.45) | — | |
| SCHEMBL2091404 | 0.73 | HRH3 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1922 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167101-A1 | NOVEL INHIBITORS OF HISTONE ACETYLTRANSFERASE P300/CBP FOR CANCER THERAPY | BAYLOR COLLEGE OF MEDICINE (US) | 2023-06-01 | — | — | US | claimed |
| EP-4132508-A1 | NOVEL INHIBITORS OF HISTONE ACETYLTRANSFERASE P300/CBP FOR CANCER THERAPY | Baylor College of Medicine (US) | 2023-02-15 | — | — | EP | claimed |
| EP-3294803-B1 | GUANIDINE GROUP CONTAINING CATALYST | SIKA TECH AG (CH) | 2020-12-09 | — | — | EP | claimed |
| CN-107735438-B | Guanidino-containing catalysts | SIKA技术股份公司 | 2020-06-09 | — | — | CN | claimed |
| US-10414875-B2 | Catalyst containing guanidine groups | SIKA TECHNOLOGY AG (CH) | 2019-09-17 | — | — | US | claimed |
| CN-108912041-A | A kind of synthetic method of diphenoxylate hydrochloride | 郑州明泽医药科技有限公司 | 2018-11-30 | — | — | CN | claimed |
| CN-106188007-B | A kind of 3- piperidyls -4- indolylmaleimides class compounds and its preparation and application | 东华大学 | 2018-08-14 | — | — | CN | claimed |
| EP-2867232-B1 | 5-AZAINDAZOLE COMPOUNDS AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2018-08-08 | — | — | EP | claimed |
| US-20180148545-A1 | CATALYST CONTAINING GUANIDINE GROUPS | SIKA TECHNOLOGY AG (CH) | 2018-05-31 | — | — | US | claimed |
| US-9963446-B2 | Oxepan-2-yl-pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use | GENENTECH, INC. (US) | 2018-05-08 | — | — | US | claimed |
| EP-1218353-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca UK Limited (GB) | 2002-07-03 | — | — | EP | claimed |
| CN-1073103-C | Compounds and compositions for treating diseases associated with tryptase activity | ARRIS PHARM CORP (US) | 2001-10-17 | — | — | CN | claimed |
| WO-2001066099-A2 | USE OF QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2001-09-13 | — | — | WO | claimed |
| WO-2001027089-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-04-19 | — | — | WO | claimed |
| WO-2001004102-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-01-18 | — | — | WO | claimed |
| CN-1226892-A | Novel compounds and compositions for the treatment of diseases associated with tryptase activity | ARRIS PHARM CORP (US) | 1999-08-25 | — | — | CN | claimed |
| EP-0934293-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1999-08-11 | — | — | EP | claimed |
| US-5776937-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-07-07 | — | — | US | claimed |
| WO-1998004537-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-02-05 | — | — | WO | claimed |
| EP-0257485-A2 | Mixture of positively inotropically acting dihydropyridines and ACE inhibitors, and their use in medicaments | BAYER AG (DE) | 1988-03-02 | — | — | EP | claimed |