Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6095091 | 0.83 | HCRTR1 (0.45) | GAAMAPTKEAP1HCRTR1HCRTR2 | |
| SCHEMBL9433364 | 0.83 | AVPR1A (0.50) | GAAMAPTKEAP1HCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL27574060 | 0.82 | HCRTR1 (0.45) | GAAMAPTKEAP1HCRTR1HCRTR2 | |
| SCHEMBL6096552 | 0.82 | GAA (0.57) | GAAMAPTRECQLAVPR1A | |
| SCHEMBL6098564 | 0.82 | HTR2A (0.43) | KEAP1PDPK1GRM5HRH4 | |
| SCHEMBL6098559 | 0.81 | HCRTR1 (0.39) | KEAP1HCRTR1HCRTR2P2RX7PDPK1 | |
| Hydrochloric Acid SCHEMBL27554175 | 0.81 | GAA (0.56) | GAAMAPTRECQLAVPR1A | |
| SCHEMBL6330018 | 0.78 | HSP90AA1 (0.47) | GAAMAPTUSP2RECQLALDH1A1 | |
| SCHEMBL8295958 | 0.77 | ALDH1A1 (0.64) | MAPTKEAP1HCRTR1HCRTR2PDPK1 | |
| SCHEMBL6095064 | 0.77 | GHSR (0.57) | GAAMAPTRECQLALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084143-B2 | N-(indolecarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2006-08-01 | — | — | US | claimed |
| US-6838461-B1 | N-(indolcarbonyl-)piperazine derivatives | MERCK PATENT GMBH (DE) | 2005-01-04 | — | — | US | claimed |
| US-20050096330-A1 | N-(indolecarbonyl) piperazine derivatives | BOETTCHER HENNING (DE) | 2005-05-05 | — | — | US | disclosed |
| CN-1364157-A | N-(indolcarbonyl) piperazin derivatives | MERCK PATENT GMBH (DE) | 2002-08-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096330-A1 | N-(indolecarbonyl) piperazine derivatives | HTR2A, HTR2B, HTR2C | GAA 2544/4885MAPT 1280/4885KEAP1 2710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.