Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 10/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5926310 | 1.00 | METAP2 (0.49) | METAP2KCNA5MCL1BCL2A1ALDH1A1 | |
| SCHEMBL5926378 | 0.88 | KCNA5 (0.47) | KCNA5MCL1BCL2A1CTSA | |
| SCHEMBL5926687 | 0.87 | KCNA5 (0.49) | KCNA5MCL1BCL2A1ALDH1A1 | |
| SCHEMBL5926308 | 0.87 | METAP2 (0.52) | METAP2KCNA5MCL1BCL2A1 | |
| SCHEMBL5927111 | 0.84 | ACLY (0.52) | KCNA5CTSA | |
| SCHEMBL5927453 | 0.82 | KCNA5 (0.51) | KCNA5MCL1BCL2A1 | |
| SCHEMBL5927393 | 0.80 | KCNA5 (0.50) | METAP2KCNA5MCL1BCL2A1CTSA | |
| SCHEMBL5926355 | 0.80 | CTSA (0.46) | KCNA5CTSA | |
| SCHEMBL5926732 | 0.79 | KCNA5 (0.51) | METAP2KCNA5MCL1CTSA | |
| SCHEMBL5926476 | 0.79 | ACLY (0.52) | KCNA5MCL1CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7122580-B2 | Aryl and heteroaryl compounds and methods to modulate coagulation | TRANSTECH PHARMA, INC. (US) | 2006-10-17 | — | — | US | disclosed |