Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.34 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.31 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6100054 | 0.91 | CHRNB2 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM4 | |
| SCHEMBL6099397 | 0.87 | CHRNB2 (0.34) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM4 | |
| SCHEMBL6097551 | 0.85 | CHRNB2 (0.34) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM4 | |
| SCHEMBL6100850 | 0.84 | CBLB (0.36) | AKT1CNR2 | |
| SCHEMBL6099401 | 0.82 | ABL1 (0.33) | CHRNB2CHRNB4CHRNA3CHRNA4AKT1 | |
| SCHEMBL6098747 | 0.82 | TAS1R3 (0.36) | CHRM4CNR2 | |
| SCHEMBL6101313 | 0.81 | MAOB (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL844152 | 0.81 | CHRNA7 (0.34) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM4 | |
| SCHEMBL843731 | 0.81 | CHRNA7 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM4 | |
| SCHEMBL6101004 | 0.80 | CHRNB2 (0.34) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030236270-A1 | Azabicyclic compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-12-25 | — | — | US | claimed |
| US-7001900-B2 | Azabicyclic compounds for the treatment of disease | PFIZER INC. (US) | 2006-02-21 | — | — | US | disclosed |
| EP-1478646-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-24 | — | — | EP | disclosed |
| US-20030236270-A1 | Azabicyclic compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-12-25 | — | — | US | disclosed |
| WO-2003072578-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236270-A1 | Azabicyclic compounds for the treatment of disease | MALT1, TPMT, CYP2B6 | CHRNB2 2627/4885CHRNB4 3181/4885CHRNA3 2220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.