Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 12/20 | 1.00 |
| ▸ | HTR1A | P08908 | 3/20 | 0.74 |
| ▸ | HTR2A | P28223 | 3/20 | 0.74 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6098063 | 0.85 | HTR7 (1.00) | HTR7HTR1AHTR2ADRD2DRD3 | |
| SCHEMBL6096886 | 0.84 | HTR7 (0.72) | HTR7HTR1AHTR2ADRD2HTR1B | |
| SCHEMBL6097288 | 0.84 | HTR7 (0.72) | HTR7HTR1AHTR2ADRD2HTR1B | |
| SCHEMBL6097629 | 0.75 | HTR7 (1.00) | HTR7HTR1AHTR2A | |
| SCHEMBL6098197 | 0.75 | HTR7 (0.64) | HTR7HTR1AHTR2ASIGMAR1 | |
| SCHEMBL6095788 | 0.72 | HTR7 (0.72) | HTR7HTR1AHTR2AALDH1A1 | |
| SCHEMBL6096316 | 0.71 | HTR7 (0.87) | HTR7HTR1AHTR2ADRD2HTR1B | |
| SCHEMBL6097398 | 0.71 | HTR7 (0.63) | HTR7HTR1AHTR2AGAA | |
| SCHEMBL6096649 | 0.71 | HTR7 (0.68) | HTR7HTR1AHTR2AGAASIGMAR1 | |
| SCHEMBL6099295 | 0.70 | HTR7 (0.62) | HTR7HTR1AHTR2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | claimed |
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | HTR7 1/4885HTR1A 3/4885HTR2A 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.