Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.95 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.82 |
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6099871 | 0.90 | KDM4E (0.80) | KDM4EHIF1AALDH1A1PKMMAPT | |
| Ethane SCHEMBL6097475 | 0.90 | KDM4E (0.77) | KDM4EHIF1AALDH1A1PKMMAPT | |
| Ethane SCHEMBL6099926 | 0.88 | KDM4E (0.75) | KDM4EHIF1AALDH1A1PKMMAPT | |
| Ethane SCHEMBL6102425 | 0.87 | KDM4E (0.73) | KDM4EHIF1AALDH1A1PKMMAPT | |
| Ethane SCHEMBL6098608 | 0.86 | KDM4E (0.72) | KDM4EHIF1AALDH1A1PKMMAPT | |
| SCHEMBL13312198 | 0.86 | PKM (0.81) | KDM4EHIF1AALDH1A1PKMMAPT | |
| Ethane SCHEMBL6097651 | 0.85 | KDM4E (0.71) | KDM4EHIF1AALDH1A1PKMMAPT | |
| Ethane SCHEMBL6099689 | 0.84 | KDM4E (0.69) | KDM4EHIF1AALDH1A1PKMMAPT | |
| SCHEMBL16832477 | 0.83 | PKM (1.00) | KDM4EHIF1AALDH1A1PKMMAPT | |
| Ethane SCHEMBL6100439 | 0.81 | KDM4E (0.65) | KDM4EHIF1AALDH1A1PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020156095-A1 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION | 2002-10-24 | — | — | US | claimed |
| US-7041664-B2 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION (US) | 2006-05-09 | — | — | US | disclosed |
| US-6894044-B2 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION (US) | 2005-05-17 | — | — | US | disclosed |
| US-6369053-B1 | CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES; ALSO USEFUL AS PROBES FOR THE LOCALIZATION OF CELL SURFACE RECEPTORS; NONPEPTIDE NK-3 RECEPTOR ANTAGONISTS | NEUROGEN CORPORATION | 2002-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156095-A1 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | KCNQ3, OPRK1, KCNQ1 | KDM4E 2712/4885HIF1A 3061/4885ALDH1A1 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.