Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 12/20 | 0.49 |
| ▸ | EGFR | P00533 | 8/20 | 0.49 |
| ▸ | FLT1 | P17948 | 3/20 | 0.47 |
| ▸ | FLT4 | P35916 | 3/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | KIF5B | P33176 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375640 | 0.85 | TRPA1 (0.54) | TRPA1KDREGFRFLT1FLT4 | |
| SCHEMBL1887966 | 0.84 | KDR (0.71) | KDREGFRFLT1FLT4RET | |
| SCHEMBL4421666 | 0.84 | TRPA1 (0.63) | TRPA1KDREGFRFLT1FLT4 | |
| SCHEMBL4375675 | 0.84 | TRPA1 (0.63) | TRPA1KDREGFRFLT1FLT4 | |
| Hydrochloric Acid SCHEMBL6489998 | 0.83 | KDR (0.70) | KDREGFRFLT1FLT4RET | |
| SCHEMBL4374482 | 0.81 | TRPA1 (0.50) | TRPA1KDREGFRFLT1FLT4 | |
| SCHEMBL6099797 | 0.77 | KDR (0.46) | KDREGFRFLT1FLT4RET | |
| SCHEMBL4421590 | 0.77 | TRPA1 (0.61) | TRPA1KDREGFRFLT1FLT4 | |
| SCHEMBL4375574 | 0.77 | ENPP1 (0.62) | KDREGFR | |
| SCHEMBL6101139 | 0.77 | KDM1A (0.53) | KDREGFRFLT4RETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492560-B2 | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2013-07-23 | — | — | US | disclosed |
| US-7074800-B1 | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2006-07-11 | — | — | US | disclosed |
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |