Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4617527 | 0.89 | SFRP1 (0.49) | PIK3CDPIK3CBPIK3CGOPRL1BRD4 | |
| SCHEMBL4617455 | 0.89 | SFRP1 (0.46) | PIK3CDPIK3CBPIK3CGBRD4LMNA | |
| SCHEMBL4616241 | 0.85 | PIK3CD (0.39) | PIK3CDPIK3CBPIK3CGOPRL1BRD4 | |
| SCHEMBL6103336 | 0.81 | HTT (0.43) | PIK3CDPIK3CBPIK3CGBRD4LMNA | |
| SCHEMBL4637629 | 0.81 | PIK3CD (0.41) | PIK3CDPIK3CBPIK3CGOPRL1BRD4 | |
| SCHEMBL4619001 | 0.80 | SFRP1 (0.41) | PIK3CDPIK3CBPIK3CGBRD4SMN1; SMN2 | |
| SCHEMBL4618967 | 0.80 | SFRP1 (0.61) | PIK3CDPIK3CBPIK3CGBRD4LMNA | |
| SCHEMBL4618971 | 0.78 | TP53 (0.47) | LMNASMN1; SMN2CNR2ALDH1A1TSHR | |
| SCHEMBL4618055 | 0.78 | GBA1 (0.50) | SMN1; SMN2CNR2ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL4733368 | 0.75 | CHRM2 (0.41) | PIK3CDPIK3CBPIK3CGOPRL1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | PIK3CD 3716/4885PIK3CB 3946/4885PIK3CG 4233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.