Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.35 |
| ▸ | CHRNG | P07510 | 1/20 | 0.35 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CHRND | Q07001 | 1/20 | 0.35 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6098954 | 0.91 | CHRNB2 (0.36) | CHRNB2CHRNA4SLC6A3SLC6A4CHRNA7 | |
| SCHEMBL6099080 | 0.87 | CHRNB2 (0.35) | CHRNB2CHRNA4SLC6A3SLC6A4CHRNA7 | |
| SCHEMBL6100566 | 0.85 | CHRNB2 (0.35) | CHRNB2CHRNA4SLC6A3SLC6A4CHRNA7 | |
| SCHEMBL6098286 | 0.84 | SCN9A (0.35) | CHRNB2CHRNA4SLC6A3SLC6A4 | |
| SCHEMBL6098192 | 0.84 | HTR4 (0.43) | CHRNB2CHRNA4SLC6A3SLC6A4CHRNB4 | |
| SCHEMBL6099134 | 0.82 | RAF1 (0.37) | CHRNB2CHRNA4SLC6A3SLC6A4 | |
| SCHEMBL6101273 | 0.81 | SLC6A4 (0.42) | CHRNB2CHRNA4SLC6A3SLC6A4CHRNA7 | |
| SCHEMBL6099436 | 0.80 | IRAK4 (0.38) | CHRNB2CHRNA4SLC6A3SLC6A4CHRNA7 | |
| SCHEMBL5226820 | 0.80 | CHRNA7 (0.37) | CHRNB2CHRNA4SLC6A3SLC6A4CHRNA7 | |
| SCHEMBL5917884 | 0.80 | F10 (0.42) | SLC6A3SLC6A4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030236270-A1 | Azabicyclic compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-12-25 | — | — | US | claimed |
| US-7001900-B2 | Azabicyclic compounds for the treatment of disease | PFIZER INC. (US) | 2006-02-21 | — | — | US | disclosed |
| US-20030236270-A1 | Azabicyclic compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236270-A1 | Azabicyclic compounds for the treatment of disease | MALT1, TPMT, CYP2B6 | CHRNB2 2627/4885CHRNA4 2863/4885SLC6A3 1166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.